Article
Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation.
Genes & development - 15 Jul 2015
Zheng Jiangge, Lang Yue, Zhang Qi, Cui Di, Sun Haili, Jiang Lun, Chen Zhenhang, Zhang Rui, Gao Yina, Tian Wenli, Wu Wei, Tang Jun, Chen Zhongzhou
Abstract excerpt
The central region of MDM2 is critical for p53 activation and tumor suppression. Upon ribosomal stress, this region is bound by ribosomal proteins, particularly ribosomal protein L11 (RPL11), leading to MDM2 inactivation and subsequent p53 activation. Here, we solved the complex structure of human MDM2-RPL11 at 2.4 Å. MDM2 extensively interacts with RPL11 through an acidic domain and two zinc fingers. Formation...
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