Article

Non-linear and time-domain sleep qEEG features predict CSF protein damage markers in early Alzheimer’s disease

2025-03-31

Abstract excerpt

<h4>Study Objectives</h4> In preclinical Alzheimer’s disease (AD), oxidative stress plays a key role in the pathogenesis by promoting non-enzymatic protein modifications that lead to the accumulation of oxidized species, established biomarkers of oxidative damage detectable in cerebrospinal fluid (CSF). These molecular alterations contribute to impaired proteostasis and the dysfunction of sleep-regulating neural...

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Literature Corpus work: 19b4a6f8-9538-552f-87f6-ab7309aa0900
DOI: 10.1101/2025.03.28.645905

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