Article

Proteogenomic signature of risk of Alzheimer’s disease and related dementia risk in individuals with a history of major depression disorder

2024-09-12

Abstract excerpt

The mechanisms linking a history of major depressive disorder (MDD) to an increased risk of Alzheimer’s disease and related dementia (ADRD) are not fully understood. Using the UK Biobank available proteomic and genomic data, we evaluated the biological mechanisms linking both conditions. In participants with a history of MDD at baseline (n=3,615), we found that plasma levels of NfL, GFAP, PSG1 were associated with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ece33929-32b6-5ab8-960c-43f2fa9c1799
DOI: 10.1101/2024.09.11.24313493

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Proteogenomic signature of risk of Alzheimer’s disease and related dementia risk in individuals with a history of major depression disorderDOI 10.1101/2024.09.11.24313493Read

Genetic Evidence Supporting a Causal Role of Depression in Alzheimer's Disease.Semantic proximity Read

Genetic investigation of non-affective psychosis and depression as causal risk factors for dementia.Semantic proximity Read

Inflammatory Biomarkers and Risk of Psychiatric DisordersSemantic proximity Read

Genetic overlap between major depression, bipolar disorder and Alzheimer’s DiseaseSemantic proximity Read

Parallel molecular alteration between Alzheimer’s disease and major depressive disorder in the human brain dorsolateral prefrontal cortex: an insight from gene expression and methylation profile analysesSemantic proximity Read

Proteomic profiling of Alzheimer’s disease and Vascular dementia reveals unique underlying signaturesSemantic proximity Read

Comprehensive Gene- and Pathway-Based Analysis of Depressive Symptoms in Older AdultsSemantic proximity Read

The risk of Alzheimer's disease and cognitive impairment characteristics in eight mental disorders: A UK Biobank observational study and Mendelian randomization analysisSemantic proximity Read

Unique genetic and risk-factor profiles in clusters of major depressive disorder-related multimorbidity trajectories.Semantic proximity Read

Genetic evidence for a causal role of depression in late-onset Alzheimer disease: A Mendelian randomization study.Semantic proximity Read

Genetic heterogeneity affects the risk of incident depression, comorbidity, and response to environment: A prospective trajectory study.Semantic proximity Read

Immunological Drivers and Potential Novel Drug Targets for Major Psychiatric, Neurodevelopmental, and Neurodegenerative ConditionsSemantic proximity Read