Article

Proteomic profiling identifies muscle-invasive bladder cancers with distinct biology and responses to platinum-based chemotherapy

2024-05-02

Abstract excerpt

<title>Abstract</title> <p>Platinum-based neoadjuvant chemotherapy (NAC) prior to radical cystectomy is the preferred treatment for muscle-invasive bladder cancer (MIBC) despite modest survival benefit and significant associated toxicities. Here, we profiled the global proteome of MIBC tumours pre- and post-NAC treatment using archival formalin-fixed paraffin-embedded tissue. We identified four pre-NAC proteomic...

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Literature Corpus work: 5daa663b-5a6e-5866-a9cf-85efd2d44a87
DOI: 10.21203/rs.3.rs-4271858/v1

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