Article

MEK1/2 and ERK1/2 mediated lung endothelial injury and altered hemostasis promote diffuse alveolar hemorrhage in murine lupus

2024-05-10

Abstract excerpt

<h4>Objective</h4> About 3% of lupus patients develop severe diffuse alveolar hemorrhage (DAH) with pulmonary vasculitis. B6 mice with pristane-induced lupus also develop DAH, but BALB/c mice are resistant. DAH is independent of TLR signaling and other inflammatory pathways. This study examined the role of the mitogen-activated protein kinase pathway (MEK1/2-ERK1/2, JNK, p38). <h4>Methods</h4> B6 and BALB/c mice...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ecdc6780-777e-5328-be07-dca5cefed6bd
DOI: 10.1101/2024.05.07.593006

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MEK1/2 and ERK1/2 mediated lung endothelial injury and altered hemostasis promote diffuse alveolar hemorrhage in murine lupusDOI 10.1101/2024.05.07.593006Read

Development of pristane induced mice model for lupus with atherosclerosis and analysis of TLR expression.Semantic proximity Read

Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus.Semantic proximity Read

Neutrophils contribute to ER stress in lung epithelial cells in the pristane-induced diffuse alveolar hemorrhage mouse modelSemantic proximity Read

Activin A-activated ALK4 induces pathogenic Th17 involvement in endothelial–mesenchymal transition in systemic lupus erythematosus-associated pulmonary arterial hypertensionSemantic proximity Read

Immune cell alterations in a pristane‐induced lupus model in C57BL/6J miceSemantic proximity Read

SH3BP2 Deficiency Ameliorates Murine Systemic Lupus ErythematosusSemantic proximity Read

Pristane-induced granulocyte recruitment promotes phenotypic conversion of macrophages and protects against diffuse pulmonary hemorrhage in Mac-1 deficiency.Semantic proximity Read

Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus.Semantic proximity Read

Elucidating the function of STING in systemic lupus erythematosus through the STING Goldenticket mouse mutantSemantic proximity Read

Hydroxychloroquine enhances efferocytosis and modulates inflammation via MerTK/Gas6 signaling in a pristane-induced lupus mouse modelSemantic proximity Read

Vasculitis in the Palmerston North mouse model of lupus: phenotype and cytokine production profile of infiltrating cells.Semantic proximity Read