Article

A Platform for Mitochondrial Profiling in Enriched Kidney Segments Under Thermodynamic Control in Mice and Humans

2025-05-09

Abstract excerpt

Mitochondrial function varies widely across kidney nephron segments, yet conventional approaches lack the resolution and control needed to assess cell-type-specific bioenergetics in situ. We present a methodological platform that enables segment-resolved profiling of mitochondrial respiration, conductance, and membrane potential in freshly isolated mouse and human nephron segments. Combining mechanical sieving and...

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Literature Corpus work: ecd2f8f0-c05f-5e8f-bac9-62c7aefdf351
DOI: 10.1101/2025.05.05.652276

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