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Article

CPT1α maintains phenotype of tubules via mitochondrial respiration during kidney injury and repair.

Cell death & disease - 14 Aug 2021

Yuan Qi, Lv Yunhui, Ding Hao, Ke Qingqing, Shi Caifeng, Luo Jing, Jiang Lei, Yang Junwei, Zhou Yang

Abstract excerpt

Impaired energy metabolism in proximal tubular epithelial cells (PTECs) is strongly associated with various kidney diseases. Here, we characterized proximal tubular phenotype alternations during kidney injury and repair in a mouse model of folic acid nephropathy, in parallel, identified carnitine palmitoyltransferase 1α (CPT1α) as an energy stress response accompanied by renal tubular dedifferentiation. Genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34392303
DOI: 10.1038/s41419-021-04085-w
PMCID: PMC8364553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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