Article
Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes.
Clinical science (London, England : 1979) - 1 May 2016
Coughlan Melinda T, Nguyen Tuong-Vi, Penfold Sally A, Higgins Gavin C, Thallas-Bonke Vicki, Tan Sih Min, Van Bergen Nicole J, Sourris Karly C, Harcourt Brooke E, Thorburn David R, Trounce Ian A, Cooper Mark E, Forbes Josephine M
Abstract excerpt
Oxidative phosphorylation (OXPHOS) drives ATP production by mitochondria, which are dynamic organelles, constantly fusing and dividing to maintain kidney homoeostasis. In diabetic kidney disease (DKD), mitochondria appear dysfunctional, but the temporal development of diabetes-induced adaptations in mitochondrial structure and bioenergetics have not been previously documented. In the present study, we map the...
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