Article

Disease Landscape-Guided Design of Neutrophil-Specific Reporters for Early and Accurate Pneumonia Detection in Vivo and in Urine

2025-05-05

Abstract excerpt

<title>Abstract</title> <p>Accurate and early detection of pneumonia is crucial for effective treatment; however, current diagnostic methods often lack the necessary specificity and sensitivity, particularly in the early stages. Herein, we begin with a comprehensive bioinformatics analysis, identifying neutrophils as key effectors in pneumonia pathogenesis, and neutrophil elastase (NE) as a critical biomarker ass...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 14b7e6d4-c933-5031-888a-ca79e5cd6e5d
DOI: 10.21203/rs.3.rs-6262419/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Disease Landscape-Guided Design of Neutrophil-Specific Reporters for Early and Accurate Pneumonia Detection in Vivo and in UrineDOI 10.21203/rs.3.rs-6262419/v1Read

Protease FRET Reporters Targeting Neutrophil Extracellular TrapsSemantic proximity Read

High-throughput, Multiplexed Assay Platform for Integrated Analysis of SepsisSemantic proximity Read

Noninvasive lung cancer detection via pulmonary protease profilingSemantic proximity Read

Enzymes in Synergy: Bacteria Specific Molecular Probe for Locoregional Imaging of Urinary Tract Infection in vivoSemantic proximity Read

Marginated neutrophils in the lungs effectively compete for nanoparticles targeted to the endothelium, serving as a part of the reticuloendothelial systemSemantic proximity Read

Nanozymes for Non-neoplastic Diseases: Catalytic Therapy RedefinedSemantic proximity Read

Design of a quinoxalinone-based AIE probe for the detection of ROS in in vitro and in vivo sepsis modelsSemantic proximity Read

Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitisSemantic proximity Read

A New Hope for Liquid Biopsies: Early Detection of Pancreatic Cancer By Means of Protease Activity Detection in Serum Applying a Hierarchical Decision StructureSemantic proximity Read

Intrinsically Selective Nanoplatforms for Precision Therapy and MonitoringSemantic proximity Read

Current and novel therapies for management of Acinetobacter baumannii -associated pneumoniaSemantic proximity Read

Activatable Nanoreporters for Real-Time Tracking of Macrophage Phenotypic States Associated with Disease Progression.Semantic proximity Read