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Article

A multistationary loop model of ALS unveils critical molecular interactions involving mitochondria and glucose metabolism.

PloS one - 1 Jan 2020

Burlando Bruno, Milanese Marco, Giordano Giulia, Bonifacino Tiziana, Ravera Silvia, Blanchini Franco, Bonanno Giambattista

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a poor-prognosis disease with puzzling pathogenesis and inconclusive treatments. We develop a mathematical model of ALS based on a system of interactive feedback loops, focusing on the mutant SOD1G93A mouse. Misfolded mutant SOD1 aggregates in motor neuron (MN) mitochondria and triggers a first loop characterized by oxidative phosphorylation impairment, AMP kinase...

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Identifiers

PMID: 33332476
DOI: 10.1371/journal.pone.0244234
PMCID: PMC7746301

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