Article

KDM4-dependent DNA breaks at active promoters facilitate +1 nucleosome eviction

2023-07-15

Abstract excerpt

When the effect of various posttranslational histone tail modifications (PTMs) on nucleosome stability was compared in an in situ assay involving agarose-embedded nuclei, the promoter proximal H3K4me3, H3K27ac and H4K8ac positive nucleosomes exhibited relative sensitivity to intercalators as compared to bulk H3-GFP or nucleosomes carrying any of the following marks: H3K27me1, H3K27me2, H3K27me3, H3K9me1, H3K9me2,...

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Literature Corpus work: ec7cff4f-309d-556d-853c-20d8a78bbd38
DOI: 10.1101/2023.07.14.548993

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