Article

Depletion of BRCA1 Potentiates Progestin-Induced Cytoskeletal Changes in an Ovarian Cancer Cell Model

2026-01-02

Abstract excerpt

<h4>ABSTRACT</h4> Individuals with Hereditary Breast and Ovarian Cancer (HBOC) syndrome carry BRCA1/2 mutations that predispose them to various cancers. Notably, this condition increases the risk of developing an aggressive ovarian cancer (OC) subtype known as high-grade serous ovarian cancer (HGSOC). The impact of progesterone (P4) on the development of OC subtypes remains unclear. Research suggests a potential...

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Literature Corpus work: ec7500d5-c9d2-5612-8f44-4645067a02d0
DOI: 10.64898/2026.01.02.697409

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