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Article

Progesterone Receptors Promote Quiescence and Ovarian Cancer Cell Phenotypes via DREAM in p53-Mutant Fallopian Tube Models.

The Journal of clinical endocrinology and metabolism - 16 Jun 2021

Mauro Laura J, Seibel Megan I, Diep Caroline H, Spartz Angela, Perez Kerkvliet Carlos, Singhal Hari, Swisher Elizabeth M, Schwartz Lauren E, Drapkin Ronny, Saini Siddharth, Sesay Fatmata, Litovchick Larisa, Lange Carol A

Abstract excerpt

CONTEXT: The ability of ovarian steroids to modify ovarian cancer (OC) risk remains controversial. Progesterone is considered to be protective; recent studies indicate no effect or enhanced OC risk. Knowledge of progesterone receptor (PR) signaling during altered physiology that typifies OC development is limited. OBJECTIVE: This study defines PR-driven oncogenic signaling mechanisms in p53-mutant human fallopian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystadenocarcinoma, Serous

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Share to Receptors, Progesterone

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Identifiers

PMID: 33755733
DOI: 10.1210/clinem/dgab195
PMCID: PMC8499172

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