Article

Isoform-Specific Gene Regulation by Progesterone Receptors Drives Divergent Phenotypes in Breast Cancer Cells

2025-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Exposure to progesterone is a recognized risk factor for breast cancer, and PGR polymorphisms are associated with various malignancies. Two progesterone receptor (PR) isoforms, full length PR-B and truncated PR-A, are expressed from the PGR gene in breast tissue and play crucial roles in normal physiology and breast cancer progression. An imbalance in the expression ratio of these isoforms, fa...

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Literature Corpus work: de174008-3da1-5f6a-9501-c516beaaef92
DOI: 10.1101/2025.05.19.654935

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