Article

Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor

2023-03-13

Abstract excerpt

<title>Abstract</title> <p>SARS-CoV-2 has demonstrated extraordinary ability to evade antibody immunity by antigenic drift. Small molecule drugs may provide effective therapy while being part of a solution to circumvent SARS-CoV-2 immune escape. In this study we report an α-ketoamide based peptidomimetic inhibitor of SARS-CoV-2 main protease (Mpro), RAY1216. Enzyme inhibition kinetic analysis established that RAY...

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Literature Corpus work: 11212b8e-0cd8-50ad-99b0-32e0b5a6ce32
DOI: 10.21203/rs.3.rs-2634509/v1

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