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Stable but confounded: brain region, not diagnosis, drives a validation-passing molecular subtype in postmortem psychiatric brain

2026-07-15

Abstract excerpt

<title>Abstract</title> <p>Molecular subtyping is widely applied to brain transcriptomes, yet subtype claims are sometimes accepted without formal tests that they reflect reproducible, disease-relevant structure. We re-analyzed three public postmortem cohorts (autism: GSE28521, GSE64018; schizophrenia, bipolar disorder, and major depression with controls: GSE80655; 384 samples in total, load-bearing analyses on 2...

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Literature Corpus work
ec68913d-27e3-53c7-befe-dd47e21188ce
DOI
10.21203/rs.3.rs-8913089/v2
Open publication

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Stable but confounded: brain region, not diagnosis, drives a validation-passing molecular subtype in postmortem psychiatric brainDOI 10.21203/rs.3.rs-8913089/v2
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