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Pathway-Based Molecular Subtyping Reveals a GABA-Collapsed Autism Subgroup and Cross-Disease Convergence with Schizophrenia in Human Cerebral Cortex

2026-02-24

Abstract excerpt

<title>Abstract</title> <p>Autism spectrum disorder (ASD) and schizophrenia are genetically heterogeneous, with hundreds of risk genes contributing to single clinical diagnoses. This heterogeneity has frustrated molecular subtyping efforts and contributed to inconsistent drug trial outcomes. We present the Pathway Subtyping Framework, an open-source pipeline that shifts analysis from individual genes to biologica...

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Literature Corpus work
7fba1e82-6a2f-50da-b2b3-f70eddb69ce1
DOI
10.21203/rs.3.rs-8913089/v1
Open publication

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Pathway-Based Molecular Subtyping Reveals a GABA-Collapsed Autism Subgroup and Cross-Disease Convergence with Schizophrenia in Human Cerebral CortexDOI 10.21203/rs.3.rs-8913089/v1
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