Article
The cross-site reproducibility of MRI morphometric phenotypes in psychiatric disorders.
Nature neuroscience - 1 Sept 2026
Cao Trang, Pang James C, Gajwani Mehul, Segal Ashlea, Holmes Alexander, Wiley Joshua F, Chopra Sidhant, Zhou Juan Helen, Chen Christopher L H, Ji Fang, Harrison Ben J, Davey Christopher G, Constable Toby, Tiego Jeggan, Hartshorn Bree, Kwee Jessica, Bellgrove Mark A, Fornito Alex
Abstract excerpt
Decades of structural magnetic resonance imaging (MRI) studies have documented alterations of gray matter morphometry in psychiatric disorders, but the field has failed to identify any consensus disease phenotypes. Here we examine whether current approaches will ever converge on such phenotypes by evaluating the consistency of brain-wide maps of gray matter volume and cortical thickness differences obtained for...
Read the complete abstract on PubMedTopics
- Humans
- Magnetic Resonance Imaging
- Phenotype
- Female
- Mental Disorders