Article
Neurobiologically Based Stratification of Recent-Onset Depression and Psychosis: Identification of Two Distinct Transdiagnostic Phenotypes.
Biological psychiatry - 1 Oct 2022
Lalousis Paris Alexandros, Schmaal Lianne, Wood Stephen J, Reniers Renate L E P, Barnes Nicholas M, Chisholm Katharine, Griffiths Sian Lowri, Stainton Alexandra, Wen Junhao, Hwang Gyujoon, Davatzikos Christos, Wenzel Julian, Kambeitz-Ilankovic Lana, Andreou Christina, Bonivento Carolina, Dannlowski Udo, Ferro Adele, Lichtenstein Theresa, Riecher-Rössler Anita, Romer Georg, Rosen Marlene, Bertolino Alessandro, Borgwardt Stefan, Brambilla Paolo, Kambeitz Joseph, Lencer Rebekka, Pantelis Christos, Ruhrmann Stephan, Salokangas Raimo K R, Schultze-Lutter Frauke, Schmidt André, Meisenzahl Eva, Koutsouleris Nikolaos, Dwyer Dominic, Upthegrove Rachel
Abstract excerpt
BACKGROUND: Identifying neurobiologically based transdiagnostic categories of depression and psychosis may elucidate heterogeneity and provide better candidates for predictive modeling. We aimed to identify clusters across patients with recent-onset depression (ROD) and recent-onset psychosis (ROP) based on structural neuroimaging data. We hypothesized that these transdiagnostic clusters would identify patients...
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