Article

Mandatory Validation Gates for Molecular Patient Stratification: A Disease-Agnostic Pathway Subtyping Framework

2026-04-28

Abstract excerpt

<title>Abstract</title> <p>Unsupervised molecular clustering is fundamental to precision medicine, yet most published subtyping studies lack standardized validation criteria, making it impossible to distinguish biological signal from statistical artifact. We present the Pathway Subtyping Framework, which enforces four mandatory validation gates—label shuffle, random gene set, bootstrap stability with adaptive thr...

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Literature Corpus work: 34bbc704-c775-5760-adaa-153d5749c444
DOI: 10.21203/rs.3.rs-9284565/v1

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