Article

Global impact of aberrant splicing on human gene expression levels

2023-09-16

Abstract excerpt

Alternative splicing (AS) is pervasive in human genes, yet the specific function of most AS events remains unknown. It is widely assumed that the primary function of AS is to diversify the proteome, however AS can also influence gene expression levels by producing transcripts rapidly degraded by nonsense-mediated decay (NMD). Currently, there are no precise estimates for how often the coupling of AS and NMD (AS-NM...

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Literature Corpus work: 9bea001b-0eba-5454-ac96-b6047db6e99c
DOI: 10.1101/2023.09.13.557588

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