Article
Translation of CircRNAs.
Molecular cell - 6 Apr 2017
Pamudurti Nagarjuna Reddy, Bartok Osnat, Jens Marvin, Ashwal-Fluss Reut, Stottmeister Christin, Ruhe Larissa, Hanan Mor, Wyler Emanuel, Perez-Hernandez Daniel, Ramberger Evelyn, Shenzis Shlomo, Samson Moshe, Dittmar Gunnar, Landthaler Markus, Chekulaeva Marina, Rajewsky Nikolaus, Kadener Sebastian
Abstract excerpt
Circular RNAs (circRNAs) are abundant and evolutionarily conserved RNAs of largely unknown function. Here, we show that a subset of circRNAs is translated in vivo. By performing ribosome footprinting from fly heads, we demonstrate that a group of circRNAs is associated with translating ribosomes. Many of these ribo-circRNAs use the start codon of the hosting mRNA, are bound by membrane-associated ribosomes, and...
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