Article

TCUP – An Open Access Tool to Predict Tissue of Origin and Cancer of Unknown Primary (CUP)

2025-08-12

Abstract excerpt

<h4>Introduction</h4> Cancer of unknown primary (CUP) remains a major diagnostic hurdle, compromising therapies that depend on accurately identifying tissue of origin. We present TCUP, an ensemble learning framework that combines Contrastive Autoencoders (CAE) and Siamese Neural Networks (SNN) with base classifiers and a meta-learning layer to classify and interpret CUP, adding biological insight through Monte-Ca...

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Literature Corpus work: ec179c7b-7e95-53ac-9112-cd81b5dfee89
DOI: 10.1101/2025.08.08.669066

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