Article

Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis

2024-05-31

Abstract excerpt

<h4>ABSTRACT</h4> Malaria parasites have evolved unusual metabolic adaptations that specialize them for growth within heme-rich human erythrocytes. During blood-stage infection, Plasmodium falciparum parasites internalize and digest abundant host hemoglobin within the digestive vacuole. This massive catabolic process generates copious free heme, most of which is biomineralized into inert hemozoin. Parasites also...

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Literature Corpus work: ebfdba6b-e395-5916-aa78-b6aa4527f7e7
DOI: 10.1101/2024.05.30.596652

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