Article
Rare and common epilepsies converge on a shared gene regulatory network providing opportunities for novel antiepileptic drug discovery.
Genome biology - 13 Dec 2016
Delahaye-Duriez Andree, Srivastava Prashant, Shkura Kirill, Langley Sarah R, Laaniste Liisi, Moreno-Moral Aida, Danis Bénédicte, Mazzuferi Manuela, Foerch Patrik, Gazina Elena V, Richards Kay, Petrou Steven, Kaminski Rafal M, Petretto Enrico, Johnson Michael R
Abstract excerpt
BACKGROUND: The relationship between monogenic and polygenic forms of epilepsy is poorly understood and the extent to which the genetic and acquired epilepsies share common pathways is unclear. Here, we use an integrated systems-level analysis of brain gene expression data to identify molecular networks disrupted in epilepsy. RESULTS: We identified a co-expression network of 320 genes (M30), which is...
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