Article

Profiling the surface proteome identifies actionable biology for TSC1 mutant cells beyond mTORC1 signaling

2018-08-01

Abstract excerpt

Loss of the TSC1/TSC2 complex leads to constitutively high mTORC1 signaling; however, pharmacological inhibition of mTORC1 in this setting produces a broad spectrum of clinical responses. We report herein several cell surface proteins upregulated by inactivation of TSC1 that present therapeutic alternatives or adjuvants to direct mTORC1 inhibition. A proteomics screen revealed that TSC1 loss most dramatically indu...

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Literature Corpus work: ebbd6805-1d28-5ff6-97d6-1d7c8939af90
DOI: 10.1101/382929

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