Article

Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and rewires the microenvironment toward an immune-suppressive state

2022-06-01

Abstract excerpt

mTORC1 regulates cell metabolism to enable cell proliferation, and is hyperactive in multiple cancer types 1, 2 . Here, we performed integrative analysis of single cell transcriptomic profiling, paired T cell receptor (TCR) sequencing, and spatial transcriptomic profiling on Tuberous Sclerosis Complex (TSC) associated tumors with mTORC1 hyperactivity, and identified a stem-like tumor cell state (SLS) linked to T...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2d889acb-983e-51aa-9235-42626aaf6ab7
DOI: 10.1101/2022.06.01.494055

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and rewires the microenvironment toward an immune-suppressive stateDOI 10.1101/2022.06.01.494055Read

Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatmentSemantic proximity Read

mTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndromeSemantic proximity Read

Signaling Node at TSC2 S1365 Potently Regulates T-Cell Differentiation and Improves Adoptive Cellular Cancer TherapySemantic proximity Read

mTOR Signaling and Neural Stem Cells: The Tuberous Sclerosis Complex ModelSemantic proximity Read

Tuberous Sclerosis Complex cell‐derived EVs have an altered protein cargo capable of regulating their microenvironment and have potential as disease biomarkersSemantic proximity Read

Single-Cell Profiling and Proteomics-Based Insights Into mTORC1-Mediated Angio+TAMs Polarization in Recurrent IDH-Mutant Gliomas.Semantic proximity Read

TSC2 S1365A mutation potently regulates CD8+ T cell function and differentiation and improves adoptive cellular cancer therapy.Semantic proximity Read

STAT1 Promotes PD-L1 Activation and Tumor Growth in LymphangioleiomyomatosisSemantic proximity Read

Autophagy Promotes Tumor-like Stem Cell Niche OccupancySemantic proximity Read

The transglutaminase 2 cancer cell survival factor maintains mTOR activity to drive an aggressive cancer phenotype.Semantic proximity Read

The genomic landscape of tuberous sclerosis complex.Semantic proximity Read

mTOR Inhibitors in Cancer: What Can We Learn from Exceptional Responses?Semantic proximity Read