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Article

Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations.

Nature communications - 1 Jan 2013

Sun Wei, Zhu Ye Julia, Wang Zhizhi, Zhong Qiang, Gao Feng, Lou Jizhong, Gong Weimin, Xu Wenqing

Abstract excerpt

Tuberous sclerosis complex is a disease caused by mutations in two tumor-suppressor genes, TSC1 and TSC2. The TSC1 protein, also known as hamartin, has a critical role in controlling mTOR signalling. TSC1 does not bear apparent sequence homology with other proteins. Here we show that the N-terminal half of yeast TSC1 forms a protease-resistant domain, which is evolutionarily conserved. The crystal structure of...

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Share to Conserved Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23857276
DOI: 10.1038/ncomms3135

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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