Article

The kinase inhibitor AT9283 selectively kills colorectal cancer cells with hyperactive NRF2

2019-10-21

Abstract excerpt

<h4>ABSTRACT</h4> Aberrant hyperactivation of NRF2 is a common event in many tumour types and associates with resistance to therapy and poor patient prognosis. The identification of ways to overcome the protection provided by NRF2 and selectively kill cancer cells addicted to NRF2 is a desirable goal. Exploiting the CRISPR/Cas9 technology, we generated colorectal cancer cell lines with hyperactive NRF2, and used...

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Literature Corpus work: ebb7ccb0-c83d-5759-990b-24d2f0ea120b
DOI: 10.1101/812909

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