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Article

A New Model for Raf Kinase Inhibitory Protein Induced Chemotherapeutic Resistance

18 Jan 2012

Abstract excerpt

Therapeutic resistance remains the most challenging aspect of treating cancer. Raf kinase inhibitory protein (RKIP) emerged as a molecule capable of sensitizing cancerous cells to radio- and chemotherapy. Moreover, this small evolutionary conserved molecule, endows significant resistance to cancer therapy when its expression is reduced or lost. RKIP has been shown to inhibit the Raf-MEK-ERK, NFκB, GRK and...

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PMID: 22279539
DOI: 10.1371/journal.pone.0029532

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