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The Ewing’s Sarcoma <i>EWS/FLI-1</i> Fusion Gene Encodes a More Potent Transcriptional Activator and is a More Powerful Transforming Gene than <i>FLI-1</i>

1993-12-01

Abstract excerpt

EWS/FLI-1 is a chimeric protein formed by a tumor-specific 11;22 translocation found in both Ewing's sarcoma and primitive neuroectodermal tumor of childhood. EWS/FLI-1 has been shown to be a potent transforming gene, suggesting that it plays an important role in the genesis of these human tumors. We now demonstrate that EWS/FLI-1 has the characteristics of an aberrant transcription factor. Subcellular fractionati...

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Literature Corpus work
eb939b96-48b4-5169-8adb-e9d7b0546f7a
DOI
10.1128/mcb.13.12.7393-7398.1993
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The Ewing’s Sarcoma <i>EWS/FLI-1</i> Fusion Gene Encodes a More Potent Transcriptional Activator and is a More Powerful Transforming Gene than <i>FLI-1</i>DOI 10.1128/mcb.13.12.7393-7398.1993
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