Article
Severe infections emerge from the microbiome by adaptive evolution
2017-03-14
Abstract excerpt
Bacteria responsible for the greatest global mortality colonize the human microbiome far more frequently than they cause severe infections. Whether mutation and selection within the microbiome accompany infection is unknown. We investigated de novo mutation in 1163 Staphylococcus aureus genomes from 105 infected patients with nose-colonization. We report that 72% of infections emerged from the microbiome, with i...
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Identifiers and source
- Literature Corpus work
- eb6f36bd-917c-552a-913e-5c4c62edc156
- DOI
- 10.1101/116681