Article
Severe infections emerge from commensal bacteria by adaptive evolution.
eLife - 19 Dec 2017
Young Bernadette C, Wu Chieh-Hsi, Gordon N Claire, Cole Kevin, Price James R, Liu Elian, Sheppard Anna E, Perera Sanuki, Charlesworth Jane, Golubchik Tanya, Iqbal Zamin, Bowden Rory, Massey Ruth C, Paul John, Crook Derrick W, Peto Timothy E, Walker A Sarah, Llewelyn Martin J, Wyllie David H, Wilson Daniel J
Abstract excerpt
Bacteria responsible for the greatest global mortality colonize the human microbiota far more frequently than they cause severe infections. Whether mutation and selection among commensal bacteria are associated with infection is unknown. We investigated de novo mutation in 1163 Staphylococcus aureus genomes from 105 infected patients with nose colonization. We report that 72% of infections emerged from the nose,...
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