Article
Evolutionary dynamics of Staphylococcus aureus during progression from carriage to disease.
Proceedings of the National Academy of Sciences of the United States of America - 20 Mar 2012
Young Bernadette C, Golubchik Tanya, Batty Elizabeth M, Fung Rowena, Larner-Svensson Hanna, Votintseva Antonina A, Miller Ruth R, Godwin Heather, Knox Kyle, Everitt Richard G, Iqbal Zamin, Rimmer Andrew J, Cule Madeleine, Ip Camilla L C, Didelot Xavier, Harding Rosalind M, Donnelly Peter, Peto Tim E, Crook Derrick W, Bowden Rory, Wilson Daniel J
Abstract excerpt
Whole-genome sequencing offers new insights into the evolution of bacterial pathogens and the etiology of bacterial disease. Staphylococcus aureus is a major cause of bacteria-associated mortality and invasive disease and is carried asymptomatically by 27% of adults. Eighty percent of bacteremias match the carried strain. However, the role of evolutionary change in the pathogen during the progression from...
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