Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections.

Abstract excerpt

During severe infections, Staphylococcus aureus moves from its colonising sites to blood and tissues and is exposed to new selective pressures, thus, potentially driving adaptive evolution. Previous studies have shown the key role of the agr locus in S. aureus pathoadaptation; however, a more comprehensive characterisation of genetic signatures of bacterial adaptation may enable prediction of clinical outcomes...

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• Anti-Bacterial Agents
• Antimicrobial Resistance in Staphylococcus
• Bacterial biofilms and quorum sensing
• Bacterial Genetics and Biotechnology