Article
Within-host evolution of Staphylococcus aureus during asymptomatic carriage.
PloS one - 1 Jan 2013
Golubchik Tanya, Batty Elizabeth M, Miller Ruth R, Farr Helen, Young Bernadette C, Larner-Svensson Hanna, Fung Rowena, Godwin Heather, Knox Kyle, Votintseva Antonina, Everitt Richard G, Street Teresa, Cule Madeleine, Ip Camilla L C, Didelot Xavier, Peto Timothy E A, Harding Rosalind M, Wilson Daniel J, Crook Derrick W, Bowden Rory
Abstract excerpt
BACKGROUND: Staphylococcus aureus is a major cause of healthcare associated mortality, but like many important bacterial pathogens, it is a common constituent of the normal human body flora. Around a third of healthy adults are carriers. Recent evidence suggests that evolution of S. aureus during nasal carriage may be associated with progression to invasive disease. However, a more detailed understanding of...
Topics
- Adult
- Asymptomatic Infections
- Carrier State
- Evolution, Molecular
- Genome, Bacterial
- Humans
- INDEL Mutation
- Nose
- Polymorphism, Single Nucleotide