Article

Simple sequence repeats power <i>Staphylococcus aureus</i> adaptation

2025-07-09

Abstract excerpt

Understanding Staphylococcus aureus adaptation is foundational for addressing the challenges posed by this pathogen. Using evolutionary convergence analysis on 7099 S. aureus genomes we uncovered frequent, reversible loss-of-function (LoF) mutations caused by simple sequence repeats (SSRs). Functional assays showed SSRs are potent, length-dependent switches that activate and deactivate genes, a mechanism exempli...

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Literature Corpus work: 78e127c4-8b89-5f5e-a78d-4055972a3bb5
DOI: 10.1101/2025.07.08.663602

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