Article
Changes in HCMV immune cell frequency and phenotype are associated with chronic lung allograft dysfunction.
Frontiers in immunology - 1 Jan 2023
Rousselière Amélie, Delbos Laurence, Foureau Aurore, Reynaud-Gaubert Martine, Roux Antoine, Demant Xavier, Le Pavec Jérôme, Kessler Romain, Mornex Jean-François, Messika Jonathan, Falque Loïc, Le Borgne Aurélie, Boussaud Véronique, Tissot Adrien, Hombourger Sophie, Bressollette-Bodin Céline, Charreau Béatrice
Abstract excerpt
Background: Human cytomegalovirus (HCMV) infection is common and often severe in lung transplant recipients (LTRs), and it is a risk factor associated with chronic lung allograft dysfunction (CLAD). The complex interplay between HCMV and allograft rejection is still unclear. Currently, no treatment is available to reverse CLAD after diagnosis, and the identification of reliable biomarkers that can predict the...
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