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Persistent and progressive acute lung allograft dysfunction is linked to cell compositional and transcriptional changes in small airways

28 Apr 2025

Abstract excerpt

BACKGROUND: ) decline concerning for chronic lung allograft dysfunction (CLAD) onset. Novel diagnostic tools are needed to identify those with ALAD who will progress to CLAD and to target appropriate therapies. We hypothesized that progressive ALAD would be associated with changes in small airway cell composition and cell-specific transcription. METHODS: decline. Cell compositional changes, pseudobulk Reactome...

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PMID: 40293382
DOI: 10.1016/j.healun.2025.03.010

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