Article
Humoral immune responses mediate the development of a restrictive phenotype of chronic lung allograft dysfunction.
JCI insight - 3 Dec 2020
Misumi Keizo, Wheeler David S, Aoki Yoshiro, Combs Michael P, Braeuer Russell R, Higashikubo Ryuji, Li Wenjun, Kreisel Daniel, Vittal Ragini, Myers Jeffrey, Lagstein Amir, Walker Natalie M, Farver Carol F, Lama Vibha N
Abstract excerpt
Understanding the distinct pathogenic mechanisms that culminate in allograft fibrosis and chronic graft failure is key in improving outcomes after solid organ transplantation. Here, we describe an F1 → parent orthotopic lung transplant model of restrictive allograft syndrome (RAS), a particularly fulminant form of chronic lung allograft dysfunction (CLAD), and identify a requisite pathogenic role for humoral...
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