Article
Protein engineering of human cytochromes P450 and their allelic variants for nanobiotechnological applications
2010-01-01
Abstract excerpt
Human cytochromes P450 (CYP) constitute one of the most important and studied classes of phase I drug metabolizing enzymes. A small group of 6-7 isoforms of the 57 identified until now accounts for 90-95% of the metabolism of clinically used drugs and can contain mutations (single nucleotide polymorphisms) that, when located in the coding regions, can lead to absent, deficient or enhanced enzyme activity. Thanks t...
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Identifiers and source
- Literature Corpus work
- eaa4f0ff-a123-567b-9cef-4bfbb9641267
- DOI
- 10.25560/11739