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Article

Nanogap-based electrical PNA chips for the detection of genetic polymorphism of cytochrome P450 2C19.

Journal of nanoscience and nanotechnology - 1 Jul 2012

Park Dae Keun, Park Hyung Ju, Lee Cho Yeon, Hong Daewha, Lee Young, Choi Insung S, Yun Wan Soo

Abstract excerpt

PNA chips for the detection of the genetic polymorphism of Cytochrome P450 2C19 (CYP2C19), a well-known enzyme related to the metabolism of therapeutic drugs, were electrically-interfaced with interdigitated nanogap electrodes (INEs). The average gap distance and effective length of the INEs were about approximately 70 nm and approximately 140/m, respectively. Those INEs having the aspect ratio of about 2000,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22966537
DOI: 10.1166/jnn.2012.6382

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