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Genome sequencing of 196 <i>Treponema pallidum</i> strains from six continents reveals additional variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar

2021-08-17

Abstract excerpt

In spite of its immutable susceptibility to penicillin, Treponema pallidum ( T. pallidum ) subsp. pallidum continues to cause millions of cases of syphilis each year worldwide, resulting in significant morbidity and mortality and underscoring the urgency of developing an effective vaccine to curtail the spread of the infection. Several technical challenges, including absence of an in vitro culture system until...

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Literature Corpus work
ea95778d-45e1-57e7-9d54-4e59b36d70d6
DOI
10.1101/2021.08.17.456619
Open publication

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Genome sequencing of 196 <i>Treponema pallidum</i> strains from six continents reveals additional variability in vaccine candidate genes and dominance of Nichols clade strains in MadagascarDOI 10.1101/2021.08.17.456619
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