Article
Clinical and genomic diversity of Treponema pallidum subspecies pallidum to inform vaccine research: an international, molecular epidemiology study.
The Lancet. Microbe - 1 Sept 2024
Seña Arlene C, Matoga Mitch M, Yang Ligang, Lopez-Medina Eduardo, Aghakhanian Farhang, Chen Jane S, Bettin Everton B, Caimano Melissa J, Chen Wentao, Garcia-Luna Jonny A, Hennelly Christopher M, Jere Edward, Jiang Yinbo, Juliano Jonathan J, Pospíšilová Petra, Ramirez Lady, Šmajs David, Tucker Joseph D, Vargas Cely Fabio, Zheng Heping, Hoffman Irving F, Yang Bin, Moody M Anthony, Hawley Kelly L, Salazar Juan C, Radolf Justin D, Parr Jonathan B
Abstract excerpt
BACKGROUND: The increase in syphilis rates worldwide necessitates development of a vaccine with global efficacy. We aimed to explore Treponema pallidum subspecies pallidum (TPA) molecular epidemiology essential for vaccine research by analysing clinical data and specimens from early syphilis patients using whole-genome sequencing (WGS) and publicly available WGS data. METHODS: In this multicentre,...
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