Article
Treponema pallidum genome sequencing from six continents reveals variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar.
PLoS neglected tropical diseases - 1 Dec 2021
Lieberman Nicole A P, Lin Michelle J, Xie Hong, Shrestha Lasata, Nguyen Tien, Huang Meei-Li, Haynes Austin M, Romeis Emily, Wang Qian-Qiu, Zhang Rui-Li, Kou Cai-Xia, Ciccarese Giulia, Dal Conte Ivano, Cusini Marco, Drago Francesco, Nakayama Shu-Ichi, Lee Kenichi, Ohnishi Makoto, Konda Kelika A, Vargas Silver K, Eguiluz Maria, Caceres Carlos F, Klausner Jeffrey D, Mitjà Oriol, Rompalo Anne, Mulcahy Fiona, Hook Edward W, Lukehart Sheila A, Casto Amanda M, Roychoudhury Pavitra, DiMaio Frank, Giacani Lorenzo, Greninger Alexander L
Abstract excerpt
In spite of its immutable susceptibility to penicillin, Treponema pallidum (T. pallidum) subsp. pallidum continues to cause millions of cases of syphilis each year worldwide, resulting in significant morbidity and mortality and underscoring the urgency of developing an effective vaccine to curtail the spread of the infection. Several technical challenges, including absence of an in vitro culture system until very...
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