Article

A novel class of non-coding variants driving DNA double-strand breaks is associated with complex genetic diseases

2025-10-17

Abstract excerpt

Previous research efforts to map the genetic determinants of complex diseases genome-wide have identified genetic variants that act at the protein level by disrupting function, or at the regulatory level by affecting gene expression. However, for most mutations, the underlying molecular mechanisms remain unknown. In addition to protein function and gene expression level, complex diseases have previously been assoc...

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Literature Corpus work: ea93c0a6-f010-5655-a394-5f454db0e737
DOI: 10.1101/2025.10.16.25338147

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