Article

Rational design of small molecule probes for investigating the mechanism of action of the chemotherapeutic agents CDDO and artemisinin

2015-01-01

Abstract excerpt

Adverse drug reactions (ADR) are a major concern for the pharmaceutical industry and health practitioners as they can cause morbidity and in severe cases mortality. ADRs are one of the major reasons why drugs fail during clinical trials so research directed at predicting ADRs to minimise failure is essential. The CDDO (2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oate) and the synthetic endoperoxide series are two pr...

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Literature Corpus work: ea860634-285b-5163-a707-6fd4bf3814d9
DOI: 10.17638/02006368

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