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Article

Marine Natural Products with P-Glycoprotein Inhibitor Properties

22 Jan 2014

Abstract excerpt

P-glycoprotein (P-gp) is a protein belonging to the ATP-binding cassette (ABC) transporters superfamily that has clinical relevance due to its role in drug metabolism and multi-drug resistance (MDR) in several human pathogens and diseases. P-gp is a major cause of drug resistance in cancer, parasitic diseases, epilepsy and other disorders. This review article aims to summarize the research findings on the marine...

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PMID: 24451193
DOI: 10.3390/md12010525

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