Article

Separately prestored proteasome components to prevent polyspermy

2025-09-04

Abstract excerpt

To ensure genome stability across generations, an egg must be fertilized by only a single sperm. However, how sperm actively contribute to preventing polyspermy has remained unknown. Here, we demonstrate that testis-specific 20S proteasome core particles (CPs) are pre-stored within the sperm heads of both mice and humans. Upon fertilization, these testis-specific 20S CPs assemble with oocyte-derived 19S regulatory...

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Literature Corpus work: ea4284cb-763d-5320-a64f-374afd7dc703
DOI: 10.1101/2025.09.01.673592

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