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Zona Pellucida Genes and Proteins: Essential Players in Mammalian Oogenesis and Fertility

19 Aug 2021

Abstract excerpt

All mammalian oocytes and eggs are surrounded by a relatively thick extracellular matrix (ECM), the zona pellucida (ZP), that plays vital roles during oogenesis, fertilization, and preimplantation development. Unlike ECM surrounding somatic cells, the ZP is composed of only a few glycosylated proteins, ZP1–4, that are unique to oocytes and eggs. ZP1–4 have a large region of polypeptide, the ZP domain (ZPD),...

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PMID: 34440440
DOI: 10.3390/genes12081266

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